Perform hands-on laboratory work in the cell line and upstream process development team contributing to the development of processes suitable for technology transfer to the cGMP manufacturing teams. An understanding of cGMP manufacturing facility constraints and their impact on development activities will be developed.
Contribute to process validation / characterization activities by performing supporting laboratory scale studies, employing DOE methodologies.
Interpret analytical data provided by the analytical team to define subsequent steps.
Deliver high quality communication to ensure an outstanding customer experience (written reports, telecons, face to face meetings)
Working as part of a site and global project team, co-ordinate multiple projects and ensure timely delivery of project work stages. Supervision of small project teams may also be required.
Cell Culture process include: Cell Line Development (routine cell culture, FACS) Process Development (ambr15 miniaturized bioreactors, 10L laboratory scale bioreactors) Process Characterization (ambr250 miniaturized bioreactors, 10L laboratory scale bioreactors)
Key Requirements
Degree/PhD or equivalent experience in a field of Science that is relevant.
Proven experience required, including a PhD or equivalent experience gained in a lab in either industry or academia, or through an industry work training program.
Detailed understanding of the theory and application of recombinant protein expression using mammalian cell culture systems.
Understanding of cGMP regulations.
Excellent problem solving, analytical and team working skills.
