Senior Research Fellow (Lipid or Polymer Formulation)

The Laboratory for RNA Delivery Therapeutics is an inter-school research laboratory across the College of Engineering and College of Science at Nanyang Technological University (NTU), focusing on the development of advanced RNA delivery technologies. The laboratory's research focuses on the design, synthesis and evaluation of novel lipid- and polymer-based delivery systems for RNA therapeutics, with particular emphasis on enhancing delivery efficiency and endosomal escape.

The laboratory is led by Prof Mary Chan-Park, President's Chair Professor at NTU Singapore and Director of the Laboratory for RNA Delivery Therapeutics. The research programme includes collaborations with leading international partners to advance next-generation RNA nanomedicines.

For more details, please view: https://www3.ntu.edu.sg/home/mbechan/

Key Job Purpose:

We are looking for a Senior Research Fellow to conduct research on the development of novel lipid- and polymer-based delivery systems for RNA therapeutics. The role will focus on the design, formulation and evaluation of stimuli-responsive nanoparticles to enhance RNA delivery and endosomal escape.

Key Responsibilities:

The Senior RF shall perform experiments himself or herself to achieve the following:

• Develop and optimize stimuli-responsive nanoparticle formulations for RNA delivery.

• Formulate lipid- or polymer-based nanoparticles with RNA cargo.

• Characterize nanoparticle physicochemical properties and formulation performance.

• Evaluate RNA transfection efficiency and endosomal escape.

• Conduct bioimaging studies of mammalian cells and RNA delivery formulations.

• Perform in vivo studies using relevant animal models.

• Analyze and interpret experimental data, including nanoparticle and delivery performance measurements.

Besides, the senior RF is expected to supervise undergraduate FYP, Masters, and PHD students in their works. The senior RF is also expected to assist in proposal writings.

Job Requirements:

• PhD in Chemistry, Chemical Engineering, Materials Science, Bioengineering, or a related discipline.

• Research experience in stimuli-responsive RNA delivery, lipid/polymer nanoparticle formulation, and RNA delivery evaluation.

• Hands-on experience in lipid or polymer formulation, bioimaging techniques (e.g. confocal microscopy, FRET, FRAP), and/or in vivo studies.

• Good publication record, communication skills, and ability to conduct independent research.

• Experience in mentoring junior researchers, graduate students, or research staff will be an advantage.

• Experience in successful proposal writings shall also be an advantage.

We regret that only shortlisted candidates will be notified.