Senior/Research Fellow, Cardiometabolic Medicine [LKCMedicine]

The Lee Kong Chian School of Medicine (LKCMedicine) trains doctors who put patients at the centre of their exemplary care. The School, which offers both undergraduate and graduate programmes, is named after local philanthropist Tan Sri Dato Lee Kong Chian. Established in 2010 by Nanyang Technological University, Singapore, in partnership with Imperial College London, LKCMedicine aims to be a model for innovative medical education and a centre for transformative research. The School's primary clinical partner is the National Healthcare Group, a leader in public healthcare recognised for the quality of its medical expertise, facilities and teaching. The School is transitioning to an NTU medical school ahead of the 2028 successful conclusion of the NTU-Imperial partnership to set up a Joint Medical School. In August 2024, we welcomed our first intake of the NTU MBBS programme, that has been recently enhanced to include themes like precision medicine and Artificial Intelligence (AI) in healthcare, with an expanded scope in the medical humanities. Graduates from the five-year undergraduate medical degree programme will have a strong understanding of the scientific basis of medicine, with an emphasis on technology, data science and the humanities.

Assistant Professor Lynn Yap is looking for a motivated Research Fellow to join her laboratory at the Lee Kong Chian School of Medicine (Novena), a medical school in Nanyang Technological University (NTU).

A/Prof Yap laboratory is working on the field of regenerative cardiology and metabolic disorders, where the team is interested in the basic and translational cardiometabolic research. The laboratory is focusing on regenerative cardiology using stem cell therapy to investigate cardio-immunology regeneration. We work with pluripotent stem cells and cardiovascular progenitor-mediated repair of myocardial infarction in small (rodents) and large (pigs) animal models. When transplanted into the animals, these progenitor cells engrafted, long-term survived and avoided ventricular arrhythmia in the animal. Therefore, providing a potential cellular therapy product for ischemic heart disease patients. In addition, we are interested in uncovering the molecular mechanism of cardiac regeneration, human graft maturation and immunology of the heart using disruptive technologies and inventions.

Lynn Yap's laboratory is pursuing medical innovations by integrating science, engineering and technology to positively impact patients lives. Therefore, this role will provide an exciting opportunity for the individual to learn and experience collaborative academic/industry research and play an important role in impacting patients lives.

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Responsibilities:

• Conduct accurate monitoring, documenting and reporting of experimental results

• Present and communicate effectively the research findings

• Assist with figures and manuscript writing for publications

• Mentor the research assistants and PhD students

• Perform and troubleshoot wet bench experiments including stem cell culture, western blotting, molecular biology, microscopy, histology, and flow cytometry

• Perform bioinformatics analysis, to analyze multi-omics results (single-cell RNAseq, spatial RNA transcriptomics, spatial proteomics)

• Perform mouse myocardial infarction experiment

• Lead large pig myocardial infarction study with collaborators

• Perform other related duties related to the work describe herein or assigned by the supervisor

Requirements:

• Ph.D. or equivalent degree with strong background and proven track record across stem cell biology, cardiology, RNA biology, therapeutics discovery, functional genomics and/or immunology with at least 2 years of work experience in a research environment.

• Good written and oral communication skills

• Track record of high-quality publications

• Demonstrated knowledge, skills, and expertise in independent scientific research includingmolecular and cell biology, histology, flow cytometry and microscopy.

• Proficient with cardiac biology or immunology.

• Experience with cardiac myocardial infarction in large or small animals

• Strong interpersonal skills and astrong team player who is organized, energetic, open-minded, highly motivated, and able to multi-task and work collaboratively in a diverse team.

• Ability to work independently, develop solutions under strict timelines and meticulous.

• Required to mentor and train PhD students, interns and RAs

• Experience with scRNAseq or spatial transcriptomics will be advantages

• Experience with mRNA and LNP technology will be welcome

• RCULA certification and experience with animal studies will be required.