Scientist

Brief Summary

Join a dynamic team in a role focused on advancing pharmacological research through innovative study design and execution. This position offers an opportunity to contribute to critical projects while honing your expertise in translational pharmacology.

Responsibilities

• Independently design and execute integrated in vitro and in vivo studies according to project objectives. Generate high-quality, decision-enabling data through rigorous experimental design, troubleshooting, statistical analysis, and interpretation. Present findings and recommendations at internal project meetings, ensuring accurate documentation and adherence to study timelines. Conduct ASO and siRNA transfection studies, performing dose-response and time-course experiments to evaluate target knockdown, potency, durability, and functional outcomes. Culture and maintain metabolic cell models, including primary hepatocytes, HepG2, C2C12 myotubes, and 3T3-L1 adipocytes. Develop and perform mechanistic assays relevant to obesity and MASH, assessing lipid accumulation, glucose uptake, insulin sensitivity, and mitochondrial respiration. Perform molecular biology techniques such as RT-qPCR/qPCR, Western blotting, ELISA/Luminex, RNA/protein extraction, and downstream analyses. Develop, submit, and maintain compliance protocols, executing efficacy and PK/PD studies in relevant mouse models. Conduct metabolic assessments and monitor various health metrics in rodent models, collecting samples for analysis and supporting bioanalytical workflows. Analyze experimental data using relevant software, applying appropriate statistical methods, and ensuring rigorous laboratory records are maintained. Prepare comprehensive reports, presentations, and study documentation to facilitate project progression.

Requirements

• Bachelor's/Master's degree in Pharmacology, Biomedical Sciences, Life Sciences, or related discipline with 10-12 years of relevant experience or PhD with 7 years of hands-on experience in pharmacology. Demonstrated expertise in study design, execution, troubleshooting, data analysis, and scientific reporting with minimal supervision. Proven experience in developing and managing compliance protocols for rodent studies. Strong understanding of experimental rigor, reproducibility, data integrity, and meticulous laboratory documentation. Excellent communication, organizational, and collaborative skills with a focus on translational research. Prior experience with RNA therapeutics (ASO/siRNA) is required experience in metabolic disease pharmacology is advantageous but not essential. Candidates lacking experience in metabolic disease indications are encouraged to apply, as comprehensive training will be provided.