Research Scientist (SXY Lab), IMCB

Job Description

The Translational Retinal Research Laboratory is looking for a passionate and driven Scientist to advance our cutting-edge work in Nucleic Acid therapeutics for retinal diseases. This role offers a unique opportunity to work at the intersection of stem cell biology, gene regulation, and translational medicine, developing and testing next-generation therapeutics for Age-related Macular Degeneration (AMD).

Responsibilities

• Develop and apply human stem cell-derived retinal epithelial and endothelial cells for therapeutic screening.
• Evaluate therapeutic uptake, trafficking, and knockdown efficiency using advanced molecular and cellular assays.
• Build and apply functional assays (e.g. migration, tube formation) to assess therapeutic outcomes
• Test lead candidates in preclinical mouse models, evaluating biodistribution and efficacy through various delivery routes
• Collaborate with a dynamic, multidisciplinary team, contributing to publications, presentations, and translational milestones.
• Drive reporting outputs including progress updates, invention disclosures, and final research reports.

Job requirements

• PhD in Biology, Biomedical Science, Biotechnology, or related field (or equivalent experience).
• Strong background in stem cell biology, with experience in epithelial or vascular endothelial differentiation is preferred.
• Expertise in cellular and molecular techniques (e.g. qPCR, immunofluorescence, confocal microscopy, flow cytometry).
• Experience in in-vitro and in-vivo (rodent) disease modelling is highly preferred.
• Proven ability to design, execute, and analyze complex experiments with attention to detail.
• Strong communication skills and a collaborative mindset, with a track record of scientific writing or high impact publication.