Research Officer, Laboratory of Chemical Biology and Functional Genomics (GIS)

Join the Chemical Biology lab at GIS to Unlock the Therapeutic Potential of targeting nucleic acids

The Yu Lab is a chemical biology lab dedicated to translational research targeting cellular nucleic acids. We integrate functional genomics, chemical biology, and molecular pharmacology to advance RNA-targeted drug discovery. Our goal is to re-engineer antisense oligonucleotides (ASOs) for gene-selective regulation, paving the way for rational drug design.

By leveraging cutting-edge gene-targeting strategies, structural biology, sequencing technologies, and computational approaches, we aim to unlock RNA and DNA as precise therapeutic target, addressing diseases linked to genomic dysregulation and undruggable pathways.

We are looking for a highly motivated Research Officer to join our team and drive/lead independent projects on innovative RNA- and DNA-targeted therapeutic discovery. This position is instantly available.

Responsibilities:

• Develop and optimize cellular assays to evaluate the efficacy of RNA-targeting strategies in cells.
• Assist in designing and conducting experiments related to CRISPR, small-molecule screening, and ASO development.
• Perform molecular biology experiments, including CRISPR-based gene regulation, plasmid construction, stable cell line establishment, and RNA-seq library preparation.
• Maintain lab operations, including reagent preparation, consumable ordering, budget tracking, and equipment maintenance.
• Engage in literature reviews, research discussions, and collaborative projects.
• Ensure project milestones are met and contribute to manuscript preparation.

Requirements:

• Bachelor or Master degree in Biological Sciences, Chemical Biology, or related fields.
• Experience in molecular biology, cell culture, RNA biology, protein engineering, CRISPR, or sequencing technologies.
• Strong organizational skills and a positive, eager-to-learn attitude.
• Driving project independently and collaboratively with PI's guidance in a fast-paced research environment.

Application Details

For inquiries or to apply, please email your CV and brief research interest to Zutao Yu ([Confidential Information]), with email title Research officer application_ASTAR. More information about the lab can be found online: and .

Why Join Us

The Genome Institute of Singapore (GIS), A.STAR is the national flagship program for genomic sciences in Singapore, with a mission to use genomics to improve public health and drive biomedical innovation. GIS offers a highly competitive remuneration package and relocation assistance. Singapore is a vibrant, cosmopolitan city-state at the heart of Asia, known for its excellent quality of life, world-class research infrastructure, and strong government support for scientific innovation.

Join us in advancing RNA and DNA-targeted therapeutics and making an impact in functional genomic medicine!