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Research Fellow (DMOAJ)

Research Fellow (DMOAJ)

National Cancer Centre Singapore
Fresher
Not Disclosed
  • Posted 5 hours ago
  • Be among the first 10 applicants

Job Description

We are seeking a highly motivated Research Fellow to join our translational immuno-oncologyteam developing bispecific therapeutic strategies for lung cancer. The successful candidate will contribute to the design, mechanistic evaluation, preclinical validation, and translational development of novel bispecificantibodies and immune-cell engagers.

We Offer

  • Opportunity to work on an impactful translational cancer immunotherapy programme focused on next-generation bispecific therapeutics for lung cancer.
  • Access to advanced platforms for flow cytometry, live-cell imaging, in vivo imaging, proteomics, and translational immune profiling.
  • A multidisciplinary academic-clinical research environment with opportunities for scientific publication, collaboration, and clinical translation.

This is a full-time position. Candidates with strong hands-on experience in cancer immunology, functional T-cell assays, bispecific/antibody therapeutics, or relevant in vivo tumor models are strongly encouraged to apply!

Key Responsibilities

  • Design, optimize, and executein vitro and in vivo studies to evaluate bispecific therapeutics for lungcancer.
  • Maintain and characterize lungcancer cell lines, primary tumor models and/or organoids, together with humanimmune cells such as PBMCs and T cells.
  • Perform functional assaysincluding tumor-cell killing, T-cell activation, proliferation, cytokinerelease, immune phenotyping, and 2D/3D co-culture studies.
  • Conduct multi-parameter flowcytometry, live-cell imaging, and mechanism-of-action studies; analyze andinterpret experimental data.
  • Support relevant mouse lungcancer models, including tumor implantation, treatment, sample collection, andbioluminescence imaging where required.
  • Prepare figures, reports,presentations, manuscripts, and grant-related materials; contribute to projectplanning and translational strategy.
  • Coordinate with internal andexternal collaborators, guide junior research staff or students whereappropriate, and support laboratory biosafety and research operations.

Key Requirements

  • PhD in Immunology, Cancer Biology, Biomedical Sciences, Molecular Biology, Bioengineering, or a closely related discipline.
  • Previous research experience in cancer immunology, antibody therapeutics, T-cell biology, or lung cancer is preferred.
  • Strong background or interest in tumor immunology, immune evasion, T-cell activation, and antibody- or engager-based cancer therapeutics.
  • Hands-on experience with mammalian cell culture, human immune cells, and functional cell-based assays.
  • Experience with multi-parameter flow cytometry and quantitative data analysis.
  • Experience with tumor cytotoxicity, T-cell activation, cytokine-release, or related immune functional assays.
  • Experience with mouse tumor models, in vivo imaging, recombinant proteins, antibody characterization, or bispecific/T-cell engager platforms is advantageous.
  • Independent, self-motivated, detail-oriented, and team-oriented, with strong scientific writing, communication, analytical, and critical-thinking skills.

More Info

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Key Skills

multi-parameter flow cytometry

tumor-cell killing

cancer immunology

in vivo tumor models

bioluminescence imaging

functional T-cell assays

T-cell activation

recombinant proteins

tumor cytotoxicity

bispecific antibody therapeutics

immune phenotyping

bispecific T-cell engager platforms

live-cell imaging

antibody characterization

2D 3D co-culture studies

quantitative data analysis

translational immune profiling

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2-5 yrs
SGD 5,300 - 7,000 per month
Singapore
Skills:
mammalian cell culture , multi-parameter flow cytometry, cancer immunology, in vivo tumor models, functional T-cell assays, Proteomics, human immune cells, recombinant proteins, bispecific antibody therapeutics, bispecific T-cell engager platforms, live-cell imaging, antibody characterization, translational immune profiling, mouse tumor models, in vivo imaging