Group Lead - Antibody–Oligo Conjugates (AOC)

Group Leader, Antibody–Oligo Conjugates (AOC)

You are an experienced bioconjugation or AOCfocused scientist who thrives in discovery. You know how to design, implement, and optimise antibody–oligo conjugates, build assays, validate constructs, and move programmes toward candidate selection. You want to lead a function, build a team, and shape an emerging therapeutic platform from the ground up.

A newly established RNAtherapeutics initiative is scaling rapidly and now seeks a Group Leader, Antibody–Oligo Conjugates to lead AOC engineering, bioconjugation workflows, assay development, and crossfunctional integration. The programme is expanding from 13 to 80 scientists and needs leaders who make things happen, build systems, and deliver progress at pace.

THE ROLE

You will lead the AOC engineering and bioconjugation strategy, implementing antibodybased tissuetargeting approaches while simultaneously building the team around you. Your work ensures that AOCs move efficiently from design conjugation assay validation precandidate stage.

This is a discoveryheavy, handson scientific leadership role where you define how the entire AOC workflow operates.

KEY RESPONSIBILITIES

Lead AOC engineering for tissuetargeting applications, including design and implementation of conjugation strategies

Build complete flowschemes for AOC discovery; from design through screening, validation, and selection

Own bioconjugation strategy and oversee the work of a Bioconjugation Scientist/Senior Scientist

Oversee antibody generation, CRO interactions, and characterisation of known binders

Act as a scientific leader, problemsolver, and good citizen within a multicultural, startupstyle team

ABOUT YOU

Strong background in bioconjugation, ADC/AOC engineering, or related antibody–nucleic acid modalities

Deep experience developing assays, validating conjugates, and understanding toxicity vs nontoxicity mechanisms

Ability to run full discovery flowschemes and drive programmes toward candidate selection

Built and managed teams.

LOGISTICS

Fulltime, onsite in Singapore

Visa sponsorship available

Very competitive benefits structure; relocation support available

Effective income tax typically 18–19% (max 24%)

Competitive Annual Salary

If you want to build a nextgeneration AOC platform inside a rapidly scaling discovery organisation, Apply now!