Group Lead - Antibody–Oligo Conjugates (AOC)

Group Leader, Antibody–Oligo Conjugates (AOC)

You are an experienced bioconjugation or AOC‑focused scientist who thrives in discovery. You know how to design, implement, and optimise antibody–oligo conjugates, build assays, validate constructs, and move programmes toward candidate selection. You want to lead a function, build a team, and shape an emerging therapeutic platform from the ground up.

A newly established RNA‑therapeutics initiative is scaling rapidly and now seeks a Group Leader, Antibody–Oligo Conjugates to lead AOC engineering, bioconjugation workflows, assay development, and cross‑functional integration. The programme is expanding from 13 to 80 scientists and needs leaders who make things happen, build systems, and deliver progress at pace.

THE ROLE

You will lead the AOC engineering and bioconjugation strategy, implementing antibody‑based tissue‑targeting approaches while simultaneously building the team around you. Your work ensures that AOCs move efficiently from design → conjugation → assay → validation → pre‑candidate stage.

This is a discovery‑heavy, hands‑on scientific leadership role where you define how the entire AOC workflow operates.

KEY RESPONSIBILITIES

Lead AOC engineering for tissue‑targeting applications, including design and implementation of conjugation strategies

Build complete flow‑schemes for AOC discovery; from design through screening, validation, and selection

Own bioconjugation strategy and oversee the work of a Bioconjugation Scientist/Senior Scientist

Oversee antibody generation, CRO interactions, and characterisation of known binders

Act as a scientific leader, problem‑solver, and good citizen within a multicultural, startup‑style team

ABOUT YOU

Strong background in bioconjugation, ADC/AOC engineering, or related antibody–nucleic acid modalities

Deep experience developing assays, validating conjugates, and understanding toxicity vs non‑toxicity mechanisms

Ability to run full discovery flow‑schemes and drive programmes toward candidate selection

Built and managed teams.

LOGISTICS

Full‑time, on‑site in Singapore

Visa sponsorship available

Very competitive benefits structure; relocation support available

Effective income tax typically 18–19% (max 24%)

Competitive Annual Salary

If you want to build a next‑generation AOC platform inside a rapidly scaling discovery organisation, Apply now!