Group Lead - Oligonucleotides Chemistry

Group Leader, Oligonucleotides Chemistry

You are an experienced oligonucleotide chemist who thrives in discoverystage environments. You want to build and lead a chemistry function, expand an emerging RNA platform, and take novel oligonucleotide designs all the way through to candidate selection. You want the combination of scientific depth, platform ownership, and the chance to shape a fastscaling therapeutic initiative from the ground up.

A newly established RNA drugdiscovery initiative-backed by longterm government support and expanding from 13 to 80 scientists; now seeks a Group Leader, Oligonucleotides Chemistry to drive platform expansion and create the next generation of oligo therapeutics.

THE ROLE

You will build and lead the oligonucleotide chemistry function, driving platform expansion beyond the liver and ensuring the chemistry capabilities are ready for true target deployment. This role blends group leadership, platform design, handson scientific problemsolving, and close collaboration with analytical development, bioconjugation, and engineering teams.

Key Responsibilities

Lead design, synthesis, purification, and characterisation of oligonucleotides through to candidate selection

Drive platform expansion, including new modalities and strategies beyond hepatic targets

Build and mentor a multidisciplinary chemistry team

About You

Deep experience in oligonucleotide chemistry and/or bioconjugation

Strong track record in design synthesis characterisation candidate selection

Experience analysing bioconjugate chemistry structures; evidence through patents is valued

Prior leadership experience (GL level or equivalent)

Logistics

Fulltime, onsite in Singapore

Visa sponsorship available

Benefits include relocation support, offsets, and tax environment where effective tax often falls around 18–19%

Competitive Salary

If you're excited by the idea of shaping an oligo discovery engine inside a fastscaling RNA initiative, apply now!