I am currently looking for a Antibody Scientist - Early Discovery for one of my R&D client specialized in RNAi and siRNA therapeutics development.

Job Title: Antibody Scientist - Early Discovery

Salary: Competitive Market Rate

Type: Full Time

Location: Singapore, Central

The Antibody Scientist will lead the discovery and optimization of antibodies for AOC/PCC conjugates targeting extrahepatic tissues, applying strong expertise in antibody engineering and characterization to drive programs from early discovery to PCC nomination.

Responsibilities

1. Lead the discovery and screening of antibodies for extrahepatic targeting applications, using established antibody discovery platforms and technologies.
Design and execute antibody engineering strategies to optimize affinity, specificity, and developability properties for AOC/PCC conjugates.
Perform comprehensive antibody characterization including binding affinity assessment, epitope analysis, and cross-reactivity profiling.
4. Collaborate closely with Senior Chemist and Senior Biologist teams to co-develop and optimize new AOC/PCC platforms for extrahepatic targeting.
Establish and maintain a seamless and effective working model with the Suzhou discovery team, including regular scientific alignment, joint experimental design, transparent data sharing, and synchronized project timelines to ensure efficient cross-site collaboration.
Manage external CRO collaborations for antibody discovery and characterization, including study design oversight, quality control, data review, and timeline management.
Drive innovation in antibody discovery workflows and contribute to IP generation and scientific publications.

Requirements:

Ph.D. in Molecular Biology, Immunology, Protein Engineering, or a related discipline with minimum 5 years of industry experience in antibody discovery and engineering.
Demonstrated industry expertise in antibody discovery technologies and antibody engineering for therapeutic applications.
Proven experience in antibody characterization including binding kinetics analysis, functional assays, and binding site characterization.
Direct experience with AOC/PCC modalities or conjugate technologies in an industry setting is highly preferred.
Strong hands-on skills in molecular biology and protein biochemistry techniques relevant to antibody development.
Proven ability to work effectively in cross-functional, cross-site project teams, with experience in establishing efficient collaboration models across geographically distributed teams.
Experience in managing external CRO collaborations for antibody discovery and characterization projects.

Antibody Scientist Early Discovery