Research Fellow – Microvascular Anastomosis Device Development

Overview

Reporting to the Principal Investigator, you will support the development and validation of a novel mechanical vessel coupler for microvascular anastomosis in reconstructive surgery. The incumbent will conduct in vitro cellular studies and support an in vivo porcine survival study, generating biocompatibility and efficacy data to advance the device toward clinical translation and regulatory submission.

Job Responsibilities

Plan, conduct, and document in vitro cellular studies, including endothelial cell viability, immunohistochemistry, fibrosis marker analysis, and cytokine profiling
Operate flow loop systems and conduct wound-healing assays to assess vascular recovery kinetics under physiological shear stress
Support material characterisation using scanning electron microscopy and assist with antithrombotic surface functionalisation testing
Coordinate and assist in vivo porcine survival study procedures, including flap surgery, Doppler monitoring, biopsy collection, and histological evaluation
Organize and support internal team meetings, IACUC coordination, and liaison with external collaborators (e.g., SEMC/NLAF)
Maintain accurate records, analyse data, and contribute to progress reports, manuscripts, and regulatory documentation
Help in the applications of future research grants

Requirements

PhD in Biomedical Engineering, Cell Biology, Bioengineering, or related qualification
Demonstrated hands-on experience in cell culture, immunohistochemistry, live/dead assays, and fluorescence/confocal microscopy
Familiarity with flow loop systems, hemodynamics, or biomaterials testing is advantageous
Prior experience with large animal (porcine) survival studies preferred; IACUC certification required or must be obtained
Proficiency in histological techniques (e.g., Masson's trichrome, Sirius red) and standard data analysis software
Strong project coordination skills to manage multi-site experiments across NUS, N.1 Institute, and SingHealth facilities
Ability to work effectively within a multidisciplinary clinical-engineering team and manage tight project timelines
Excellent written and verbal communication skills for scientific reporting, manuscript preparation, and grant documentation

Research Fellow, NUCOHS