Senior Research Officer, Immune Cell Manufacturing (BTI)

We are looking for a highly motivated candidate to join the immune cell manufacturing group at the Bioprocessing Technology Institute (BTI). Regulatory T cells (Tregs) are a key player in immune tolerance in the body and their use as a cell therapy treatment for autoimmune disease or organ transplant has been growing globally. We and our clinical collaborators aim to use chimeric antigen receptor (CAR) technology to redirect the function of Tregs towards therapeutic targets. This project will contribute towards developing a CAR-Treg manufacturing and quality control (QC) pipeline for transplant tolerance in Singapore. Our team will be using cell engineering strategies to improve the purity and efficacy of our manufactured Tregs, optimizing for clinical success.

Job description: Wet lab:

• Isolation, transduction, and expansion of PBMC-derived Tregs to support process development work.
• Perform molecular and immunological assays to assess the quality and specificity of Tregs.
• Record experimental findings and present analysis results.
• This role will occasionally require work beyond regular hours and on weekends during crucial timepoints.

Lab Management:

• Handling of lab inventory and the procurement of equipment and consumables.
• Facilitate laboratory maintenance, lab safety, and housekeeping of lab and equipment.

Requirements:

. Bachelor degree in Biology, Immunological Sciences, Biomedical Engineering, Biotechnology or relevant disciplines.

. Key skills and areas of experience required: Flow Cytometry, PBMC isolation, Immune Cell Culture, Lab management experience (2 years minimum).

. Highly motivated and able to work independently after training.

. Team player with good interpersonal skills in order to communicate and work well with group members and collaborators.