Scientist, Laboratory of Regulatory Translatomics and RNA Signaling (GIS)

The Genome Institute of Singapore (GIS) is Singapore's flagship institute for the genomic sciences. The Agency for Science, Technology, and Research (A.STAR) is the parent funding body for the GIS and has a long-term commitment to advance science and develop innovative technology to further economic growth and improve lives. As one of the worlds premier genomic centres, the GIS integrates genetics, genomics, high-throughput biology, and data science to gain fundamental, translational, and clinical insights into human disease and health (https://www.a-star.edu.sg/gis/).

The , at Genome Institute of Singapore (GIS) A.STAR, conducts cutting-edge research on post-transcriptional regulation in refractory cancers and develops RNA therapeutics. The lab collaborates with academia, clinical groups, and industries, to combine their RNA mechanistic studies with AI and therapeutic platforms to target cancer and other disease.

The lab is seeking motivated postdoctoral Fellows to study 3 projects:

• ribosome and translation mechanisms changes in the tumour microenvironment
• circRNA functional analysis in cells and extracellular vesicles in refractory cancers
• RNA therapeutic development

Experience in cell and molecular biology, RNA profiling and cell culture techniques would be needed. Expertise with immune cells and immune analysis is especially appreciated, or with primary cells including patient samples, organoids or in vivo models, or with multi-omic informatic analysis. The candidates will work on their individual projects with the PI and the team, and with industry and academic collaborators to perform RNA and cancer investigations, develop new assays and therapeutics, develop and perform profiling assays, and assist in the day-to-day operation of the lab.

Interested applicants should submit their CV, a cover letter detailing relevant experience and research interests, and a brief 1 page summary of their ideal project goal with 3 aims as well as their long term goals to

Key Requirements

• PhD degree in Life Sciences, Genomics, Molecular Biology, or a related field.
• Experience with cell and molecular biology techniques including cell culture, RNA sequencing, RNA analyses, cancer cell biology techniques. Experience with primary immune cells and immune analysis, or with patient samples, organoids or in vivo models, and/or profiling analysis will be preferred.
• Strong organizational skills and attention to detail in experimental procedures and data management, as well as experience in troubleshooting and projecting alternatives.
• Ability to work independently with mentoring support as well as work collaboratively in a multidisciplinary team environment.