Job Description
Job Description
The Research Pathologist will provide expert pathology input to support and advance translational research within the Experimental Therapeutics Program, with a primary focus on solid tumors, particularly breast cancer and nasopharyngeal cancer. The role is integral to bridging clinical pathology with laboratory-based discovery, biomarker development, and therapeutic innovation, contributing to precision oncology and investigator-initiated clinical trials.
Research Support and Pathology Expertise- Perform detailed analysis and interpretation of morphological features of human clinical specimens for research purposes.
- Provide expert scoring and interpretation of histological and molecular pathology assays, including immunohistochemistry (IHC), in situ hybridization (ISH), and fluorescence in situ hybridization (FISH).
- Correlate pathological findings with molecular, genomic, and clinical data to support biomarker discovery and validation.
- Lead the development, optimization, and validation of pathology-based research platforms, including but not limited to:
- Immunohistochemistry (IHC) assays
- Construction and utilization of tissue microarrays (TMAs)
- Laser capture microdissection (LCM)
- Automated staining platforms (autostainers)
- Digital slide scanning and imaging systems
- Advanced light, fluorescence, and confocal microscopy systems
- Ensure quality control, standardization, and reproducibility of pathology workflows in compliance with research and institutional standards.
Project Leadership and Scientific Contribution
- Provide scientific leadership for pathology-driven and pathology-enabled research projects within the laboratory and across collaborative programs.
- Contribute pathology expertise to translational studies involving novel therapeutics, predictive biomarkers, liquid biopsycorrelated tissue analyses, and pharmacogenetic research.
- Support clinical trialrelated pathology activities, including biomarker-driven patient stratification and correlative studies.
Supervision, Training, and Mentorship
- Supervise, mentor, and train junior research staff, students, and fellows in histopathology techniques, assay interpretation, and good laboratory practices.
- Foster a culture of scientific rigor, critical thinking, and continuous learning within the pathology component of the program.
Scientific Communication and Grants
- Assist in the preparation, review, and compilation of manuscripts, abstracts, reports, and grant applications.
- Contribute to data interpretation, figure preparation, and pathology-related sections of scientific publications and funding proposals.
Collaboration and Stakeholder Engagement
- Work closely with clinicians, molecular biologists, bioinformaticians, and clinical trial teams in a multidisciplinary research environment.
- Provide pathology consultation and input to internal and external collaborators as required.
Requirements
Essential Qualifications
Preferred Experience And Skills- Several years of experience as a diagnostic histopathologist or surgical pathologist.
- Hands-on experience in one or more of the following:
- Immunohistochemistry (IHC)
- Laser capture microdissection
- Construction and analysis of tissue microarrays
- Diagnostic molecular pathology or molecular biology techniques
- Strong understanding of disease pathogenesis and pathological processes at the tissue and cellular level.
Competencies and Attributes
- Ability to work independently with minimal supervision while managing multiple projects.
- Excellent written and spoken English communication skills.
- Strong scientific writing, reporting, and data interpretation capabilities.
- Demonstrated collaborative mindset and ability to work effectively in multidisciplinary and translational research teams.
- High level of professionalism, attention to detail, and commitment to research integrity.
