Research Officer/ Senior Research Officer (Ref: NHCS/RO/SRO/D)

You will be part of the research team under the Heart Protection theme at the National Heart Research Institute of Singapore (NHRIS), National Heart Centre of Singapore (NHCS). The team aims to discover new treatments to protect the heart from acuteischaemia/reperfusion injury and prevent heart failure. Our translational research encompasses cell and rodent models of atherosclerosis, acutemyocardial infarction, genetic cardiomyopathy, and heart failure nanoparticles for therapeutic delivery to the ischaemic heart clinical studies and the use of induced pluripotent stem cell (iPSC)-derived cardiomyocytes to model cardiac diseases and identify novel therapeutic targets - all with the goal of accelerating the translation of scientific discoveries into effective treatments for patients.

Your key responsibilities include reprogramming somatic cells into iPSCs and differentiating them into cardiac and non-cardiac lineages, performing molecular biology and imaging-based assays (including qPCR, Western blot, ELISA, and fluorescence and confocalmicroscopy), and contributing to the preparation of presentations, grant applications, reports, and manuscripts for publication.

You will also help maintain laboratory efficiency and safety protocols, and assist with procurement, while working within a dynamic, multidisciplinary team that collaborates with clinicians and scientists locally and internationally. This role offers opportunities for professional growth, scientific authorship, and meaningful contribution to translational cardiovascular research.

Requirements:

• Bachelor's degree in Life Sciences, with a specialisation in Molecular Biology, Cell Biology, Biochemistry, or a related field.
• At least 2 years experience in a wet-lab research role.
• Proficient in pluripotent stem cell reprogramming and culture, molecular techniques (including RNA/protein extraction, transfection, and gene knockdown/knockout approaches such as siRNA and CRISPR/Cas9), imaging, and flow cytometry.
• Experience with data analysis software such as GraphPad Prism and ImageJ would be an advantage.
• Able to work independently in a fast-paced environment, with strong attention to detail and meticulous record-keeping.
• A collaborative team player with good communication, organisational, and multitasking skills.

• Documented proof of:

(i) Measles (or MMR -Mumps, Measles and Rubella) vaccination or serological evidence of measles immunity and

(ii) Tdap (Tetanus, Diphtheria and Pertussis) vaccination received within the last 10 years, as required for all healthcare workers under the Healthcare Services Act.

Applicants without these vaccinations may apply if they commit to completing the required vaccination(s) before work commencement, upon successful job offer.