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Job Description
Chronic Hepatitis B (CHB) remains a major global health challenge, and functional cure, defined by HBsAg loss and immune restoration , is rarely achieved.
Our multidisciplinary program integrates clinical cohorts with mechanistic laboratory studies to uncover how hepatocytes transition from a pro-viral tolerant state to an immune-reactive flare state that precedes viral clearance.
This research aims to identify molecular triggers and therapeutic targets that drive immune-mediated HBV flares, combining hepatocyte biology, RNA therapeutics, and spatial transcriptomics.
Key Responsibilities
- Perform cell culture and molecular assays (HepAD38, HepG2, Huh7, primary hepatocytes, and co-culture systems).
- Conduct HBV replication and gene expression analyses (RNA/DNA extraction, qPCR, ELISA, Western blotting).
- Assist with RNA therapeutics and GalNAc-ASO delivery studies in hepatocyte models.
- Maintain meticulous experimental records, reagent inventories, and safety documentation.
- Support data analysis and visualization (Excel, GraphPad, or Python/R if skilled).
- Liaise with clinical teams and collaborators on translational aspects of the project.
Qualifications
- Bachelor's degree in Life Sciences, Biomedical Sciences, or Molecular Biology (recent graduates are welcome).
- Prior experience in cell culture and molecular biology is essential.
- Experience with hepatocyte or viral systems (HBV, HCV, etc.) is an advantage.
- Strong work ethic, curiosity, and ability to learn new techniques quickly.
- Excellent organizational, communication, and teamwork skills.
Training & Opportunities
- Exposure to cutting-edge platforms: RNA therapeutics, AAV-HBV1.2 mouse models, and spatial transcriptomics (CosMx).
- Opportunity to contribute to high-impact publications and national translational HBV consortia.
- Ideal stepping stone for candidates aiming for PhD training or biomedical research careers.
