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ANTER CONSULTING PTE. LTD.

Process Engineer (TCU)

Early Applicant
  • Posted 22 days ago
  • Be among the first 10 applicants
5-8 Years
SGD 5,500 - 7,500 per month

Job Description

Role of TCUs in Downstream Processing

  • Chromatography SkidsTCUs keep buffers and columns at consistent temperatures to ensure predictable protein binding, elution, and recovery.
    Even slight temperature shifts can change protein conformation or resin performance.
  • Filtration Systems (UF/DF, Sterile Filtration)Maintain temperature of product and buffer solutions during ultrafiltration/diafiltration to optimize flux and prevent protein aggregation.
    Ensure sterile filters operate within validated thermal ranges.
  • Centrifuges & Harvest SystemsTCUs provide cooling to reduce shear and prevent product degradation during cell harvest or clarification.
  • Formulation & Final Fill PrepMaintain product bulk at controlled temperatures to ensure stability before sterile filtration and filling.
  • Storage Tanks & Intermediate Hold VesselsJacketed vessels with TCU loops stabilize bulk drug substance at setpoints (often 2-8C or controlled room temp) between downstream steps.
  • Cold Chain IntegrationSupport controlled transfer between unit operations and alignment with cold rooms or blast freezers.

More Info

Industry:Other

Function:Downstream Processing

Job Type:Permanent Job

Date Posted: 08/09/2025

Job ID: 125773965

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Last Updated: 08-09-2025 08:41:32 PM
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