Director, Therapeutic Antibody Discovery.

Job Summary:

We are seeking a highly skilled and motivated Director of Therapeutic Antibody Discovery to lead our antibody therapeutics discovery programs at Hengrui Pharma. The successful candidate will oversee the identification, engineering, and development of therapeutic antibodies from target discovery through preclinical development. This role requires exceptional leadership, a deep understanding of antibody biology, and the ability to drive innovative antibody discovery strategies. The Director will be responsible for leading cross-functional teams and managing collaborations with internal and external partners to ensure the successful advancement of antibody-based therapeutics.

Key Responsibilities:

- Leadership and Strategy:

- Lead and manage the antibody drug discovery team, overseeing antibody generation, engineering, and optimization efforts.

- Develop and implement strategies for the discovery and development of novel therapeutic antibodies, aligned with company goals and therapeutic priorities.

- Provide scientific leadership to ensure the successful identification and optimization of antibodies with therapeutic potential, including monoclonal, bispecific, and other engineered antibody formats.

- Project Management:

- Lead cross-functional teams including protein engineers, immunologists, pharmacologists, and bioinformaticians to advance antibody programs from target validation to candidate selection.

- Manage project timelines, resources, and budgets to ensure timely delivery of key project milestones.

- Guide the design and execution of in vitro and in vivo studies to assess antibody efficacy, pharmacokinetics, safety, and manufacturability.

- Research and Development:

- Oversee antibody discovery efforts using a range of technologies, such as phage display, hybridoma technology, B-cell sorting, or next-generation sequencing (NGS)-based approaches.

- Drive antibody engineering efforts, including affinity maturation, humanization, optimization of stability, and formulation.

- Collaborate with bioinformatics and target discovery teams to identify novel targets for antibody therapeutics.

- Stay current with advances in antibody technologies and incorporate new methods to enhance discovery and development capabilities.

- Collaboration and Partnership:

- Establish and maintain strong working relationships with internal and external partners, including CROs, academic collaborators, and industry partners.

- Foster collaborations with external experts and organizations to advance the company's antibody discovery efforts.

- Represent the company at scientific meetings and conferences, showcasing achievements in antibody drug discovery.

- Regulatory and Compliance:

- Ensure compliance with all relevant regulatory requirements and company quality standards during the antibody discovery and development process.

- Prepare, review, and contribute to scientific publications, regulatory filings, and internal reports.

Qualifications:

- Education: Ph.D. in immunology, molecular biology, biochemistry, or a related field with a focus on antibody biology or therapeutic antibodies.

- Experience:

- 7+ years of experience in antibody drug discovery or biologics development, with demonstrated success in advancing antibody-based therapies through preclinical stages.

- Proven experience leading cross-functional teams in a pharmaceutical or biotech setting.

- Expertise in antibody generation, engineering, and optimization techniques such as phage display, hybridoma, or transgenic animal platforms.

- Skills:

- Strong knowledge of antibody structure-function relationships, antibody engineering (e.g., humanization, bispecifics, antibody-drug conjugates), and immune response modulation.

- Demonstrated experience with antibody discovery platforms and screening methods.

- Excellent leadership, organizational, and communication skills with the ability to guide teams and manage complex projects.

- Strong problem-solving skills and the ability to think innovatively to overcome challenges in antibody discovery.

Preferred Qualifications:

- Experience with bispecific antibodies, antibody-drug conjugates (ADCs), or immune checkpoint inhibitors.

- Familiarity with preclinical and clinical development processes, including IND-enabling studies.

- Knowledge of therapeutic areas such as oncology, autoimmune diseases, or infectious diseases where antibody therapeutics are particularly relevant.

Benefits:

- Competitive salary and performance-based bonuses.

- Comprehensive health insurance.

- Opportunities for professional development and career growth.

Application Process:

Interested candidates should submit their CV and a cover letter outlining their experience in drug target identification and validation, and their contributions to drug discovery efforts.

Joining the Hengrui R&D center in Singapore offers a unique opportunity to be part of a leading global pharmaceutical company dedicated to cutting-edge research and development. If you are passionate about drug discovery and want to make a significant impact in the field of medicine, we invite you to explore the exciting career opportunities available at Hengrui Pharma. A highly competitive remuneration package will be provided.

For more information about the company, please visit our website (https://www.hengrui.com/en/about.html). To apply, please contact our recruitment team: Ms. Ada Shao via [Confidential Information]

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