parameter estimation , computed tomography , Machine Learning, Python, Statistical Modelling, Medical Imaging, sensitivity analysis, Agent-based modelling, Computational modelling, Numerical Simulation, Mechanobiology modelling, Multiphysics modelling, Bone biology, image analysis, Data-driven modelling, Model calibration, model validation, Skeletal mechanobiology, Organoid-derived biological datasets, Morphometric analysis, osteoporosis, Tissue remodelling simulations